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As the left inferior fronto-occipital fasciculus (IFO) showed the most consistent decrease in integrity in T1DM patients compared to controls we selected the mean FA-value of this tract for each participant, to determine correlations between FA of that particular tract, disease variables and cognitive functions. Analyses were corrected for age, gender, depressive symptoms and multiple comparisons. Cognitive functions were assessed using an elaborate cognitive test-battery. Using the diffusion toolbox and tract-based-spatial-statistics (TBSS), part of FSL4.1 software, we calculated fractional anisotropy (FA), as a marker of tract integrity. One hundred T1DM patients and 49 controls underwent MRI, including diffusion tensor imaging (DTI) with 60 directions of encoding. We aimed to identify changes in tract integrity and determine the relationship with disease variables and cognitive functions. SNOEK, MICHAELA DIAMANT, Amsterdam, The Netherlands Type 1 diabetes (T1DM) is associated with white matter focal lesions and volume loss and cognitive changes. IJZERMAN, FREDERIK BARKHOF, MARTIN KLEIN, FRANK J. 867-P White Matter Tract Integrity in Type 1 Diabetes in Relation to Disease Parameters and Cognition EELCO VAN DUINKERKEN, PETRA J.W. A past history of weight, which does not require laboratory measurements, could be used to identify both undiagnosed diabetes and pre-diabetes.
This large cohort study has clarifi ed the usefulness of weight history as a screening tool for detecting high risk populations. We observed similar results in predicting the risk of pre-diabetes. Results of the investigation of the combined effect of present adiposity (BMI 25 or 10 kg) on prevalence of undiagnosed diabetes and pre-diabetes showed that a history of Δ weight (maximum - 20 y) >10 kg increased the risk of having undiagnosed diabetes by 72% (41-110%) in lean men and by 97% (100-83%) in obese men. An additional adjustment for present adiposity attenuated the association although it remained signifi cant. Results of logistic regression analysis showed that each 5-kg increment in Δ weight (maximum - 20 y) increased the risk of having undiagnosed diabetes by 39% (95% CI 33-46%) and that of pre-diabetes by 25% (22-28%). Prevalence of undiagnosed diabetes or pre-diabetes was 7, respectively, among the participants. Pre-diabetes was defi ned as FPG mg/dl and/ or HbA1c %. Undiagnosed diabetes was defi ned as a fasting plasma glucose level (FPG) 126 mg/dl and/or HbA1c 6.5% with no history of diagnosed diabetes. Information on weight at age 20 y and lifetime maximum weight was retrospectively obtained using a standard questionnaire. 3 of 9 measures showed statistically signifi cant (p20 y who undertook a health examination.
Test-retest reliability measured by intraclass correlation ranged from.82 to.93 (median=.86).
1 CLINICAL THERAPEUTICS/NEW TECHNOLOGY GLUCOSE CATEGORY MONITORING AND SENSING Inter-item agreement (alpha) for DMSRQ measures ranged from.71 to.93 (median=.86).